Rachael M. Lucero

Biochemical and physiological characterization of Aedes aegypti midgut chymotrypsin

This study characterizes the activity and role of Aedes aegypti chymotrypsin in blood digestion, showing its substrate specificity and the presence of a protease network, with EcR regulating its expression.

Comprehensive proteolytic profiling of Aedes aegypti mosquito midgut extracts: Unraveling the blood meal protein digestion system

This study identifies midgut proteases in Aedes aegypti mosquitoes and their role in blood meal digestion using MSP-MS, revealing shifts in proteolytic activity and substrate specificity.

Peripheral mutations underlie promiscuous transport of quaternary ammonium antiseptics by Small Multidrug Resistance transporters

The paper identifies peripheral mutations that enable promiscuous transport of quaternary ammonium antiseptics by SMR transporters, revealing that substrate preference changes through mutations outside the binding pocket.