Pharmacology & ToxicologyMolecular Therapy — Nucleic AcidsPeer-reviewed
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Biodistribution of mRNA vaccines in rats: Enrichment in injection site and lymph tissues and rapid clearance without tissue persistence
Susan M.G. Goody, Christopher Rowbottom, Yun Liu, Nancy Chen
Three mRNA-LNP products sharing one lipid matrix show rat intramuscular biodistribution (injection site, lymph nodes, spleen) and rapid clearance, with no Spike accumulation after repeat dosing.