Yun Liu

Precision cooling assists electrical stimulation: Breaking selectivity barriers in nerve control

The paper shows that local cooling improves the selectivity of electrical stimulation in nerves by reducing unwanted activity and enabling directional control.

RegimeFormer: A Large Protein Model of Global Perturbation Regimes

RegimeFormer identifies protein perturbation regimes using a large-scale model and atlas, improving prediction accuracy and enabling downstream applications.

c-Fos enhances influenza virus replication by stabilizing the M2 protein and promoting autophagosome accumulation

Foxf1 is required for the specification and maintenance of pulmonary capillary identity

This study identifies Foxf1 as essential for maintaining pulmonary capillary identity in mice, with implications for human disease.

Functional orthogonality of WRN inhibitor resistance enables alternating therapy and mutation-tolerant inhibitor design in MSI-H cancers

This study shows that resistance to different WRN inhibitors in MSI-H cancers creates orthogonal vulnerabilities, enabling alternating therapy and mutation-tolerant inhibitor design.

Biodistribution of mRNA vaccines in rats: Enrichment in injection site and lymph tissues and rapid clearance without tissue persistence

Three mRNA-LNP products sharing one lipid matrix show rat intramuscular biodistribution (injection site, lymph nodes, spleen) and rapid clearance, with no Spike accumulation after repeat dosing.

Survivin inhibition induces PD-L1 expression through cGAS stabilization and attenuates antitumor immunity

This study shows that Survivin inhibition increases PD-L1 expression via cGAS stabilization, leading to immune evasion and reduced antitumor immunity.

Cholesterol esterification blockade boosts immunotherapy and reduces liver cancer relapse

This study identifies SOAT1 as a target for improving immunotherapy and reducing liver cancer relapse by blocking cholesterol esterification.

A hierarchical nickel organic framework confers high conductivity over long distances in cable bacteria

This paper identifies the molecular structure of periplasmic fibres in cable bacteria, revealing a nickel-based organic framework that enables long-distance electron transport.

FOSL2 regulates gonadotropin-dependent folliculogenesis through feedback amplification of FSH/FSHR signaling

This study identifies FOSL2 as a key regulator of FSH/FSHR signaling in folliculogenesis, showing it enhances FSHR transcription and forms a self-amplifying loop critical for reproductive function.

Whole genome analysis of the methylome and hydroxymethylome in normal and malignant lung and liver

The paper analyzes DNA methylation and hydroxymethylation across normal and cancerous lung and liver tissues, revealing their roles in gene expression regulation and differential methylation regions.

Whole-genome sequencing of an advanced case of small-cell gallbladder neuroendocrine carcinoma

This study performs whole-genome sequencing on an advanced case of small-cell gallbladder neuroendocrine carcinoma to identify genetic alterations and potential biomarkers.