Yizhe Sun

The paper analyzes subclonal gene dosage effects in cancer using DNTR-seq, finding additive and compensatory transcriptional impacts and identifying transient clonality in ovarian and soft tissue sarcomas.

This study identifies PRDM1 as a key regulator of adaptive NK cell enrichment and functional activation in cervical cancer following chemoradiotherapy.

This study identifies a non-canonical ovarian tumor peptide that induces memory-like features in NK cells through HLA-E engagement and receptor interaction.

This study shows that antigen-specific memory NK cells can be generated in ovarian cancer, enhancing their cytotoxicity and tumor reactivity through NKG2C/A-HLA-E/ABC interactions and CXCR2-mediated migration.