Dhifaf Sarhan

The paper analyzes subclonal gene dosage effects in cancer using DNTR-seq, finding additive and compensatory transcriptional impacts and identifying transient clonality in ovarian and soft tissue sarcomas.

This study identifies a non-canonical ovarian tumor peptide that induces memory-like features in NK cells through HLA-E engagement and receptor interaction.

This study integrates chromatin accessibility and transcriptomics data from ovarian tumor-infiltrating adaptive NK cells to identify key transcription factors and their regulatory networks.

This study shows that antigen-specific memory NK cells can be generated in ovarian cancer, enhancing their cytotoxicity and tumor reactivity through NKG2C/A-HLA-E/ABC interactions and CXCR2-mediated migration.

This study identifies gender-specific microbial dysbiosis in pancreatic cancer patients using microbiome data from 191 samples, revealing sex-related differences in bacterial composition and abundance.

This study shows that IL-21 enhances aNK cell expansion and cytotoxicity against tumors, with tumor lysate boosting their efficacy, validated in a zebrafish model.