Author

John A Olson

Vanderbilt UniversityORCID 0009-0000-9654-6611Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

John A. Olson1 paper · Vanderbilt University

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Eli Fritz McDonaldiD· 2 shared Jens MeileriD· 2 shared Lars PlateiD· 2 shared Minsoo KimiD· 2 shared Andrew G. McKeeiD· 1 shared Austin Tedman· 1 shared Catherine Foye· 1 shared Charles P. KuntziD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Eli Fritz McDonaldORCID

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2 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedApr 22, 2025

Proteostasis Landscapes of Cystic Fibrosis Variants Reveals Drug Response Vulnerability

Eli Fritz McDonald, Minsoo Kim, John A. Olson…·Lars Plate

The paper uses proteomics and computational modeling to analyze CFTR variants, identifying structural vulnerabilities in NBD1 that limit corrector efficacy and suggesting secondary mutations as a therapeutic strategy.

10 citationstop 4%

humanproteomics

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BiochemistrybioRxivApr 3, 2025

General Trends in the Calnexin-Dependent Expression and Pharmacological Rescue of Clinical CFTR Variants

Austin Tedman, John A Olson, Minsoo Kim…·Jonathan P. Schlebach

This study investigates how calnexin modulates the expression and pharmacological rescue of CFTR variants using deep mutational scanning, revealing its role in CFTR assembly and variant-specific corrector responses.

DOI 10.7554/elife.107180

humandeep learning

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