Minsoo Kim

This study uses DIA proteomics to analyze age-related changes in proteostasis and UPR dynamics in human neurons and mouse glia co-cultures, revealing cell-type-specific aging responses.

The paper identifies SCCPDH as an off-target of VX-445 using a photoaffinity ligand and chemoproteomics, showing metabolic dysregulation and potential clinical implications.

The paper uses proteomics and computational modeling to analyze CFTR variants, identifying structural vulnerabilities in NBD1 that limit corrector efficacy and suggesting secondary mutations as a therapeutic strategy.

This study investigates how calnexin modulates the expression and pharmacological rescue of CFTR variants using deep mutational scanning, revealing its role in CFTR assembly and variant-specific corrector responses.

The paper uses Rosetta comparative modeling to generate structural models of ΔF508 CFTR and its variants, revealing how the mutation destabilizes the protein and how drugs like VX-809 stabilize it.