Oncogenic Ras-Src-cortactin signaling rewires actin-generated forces to drive basement membrane rupture and initiate breast cancer invasion
Eric Platz‐Baudin, Julian Eschenbruch, Yannick Herfs, Georg Dreissen, Ronald Wein, Emiel P. C. van der Vorst, Michael Rose, Rudolf Merkel, Erik Noetzel
This study identifies an HRas-Src-cortactin-Arp2/3 signaling axis that drives basement membrane rupture and breast cancer invasion through mechanical stress and cortical tension.
bioRxiv · Apr 18, 2026 · PreprintCancer Biology