Author

Kaila E. Nayvelt

The University of Texas at AustinORCID 0009-0001-0744-2632Unclaimed ORCID profile · follow to get notified of new preprints

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Synthetic Biology· 1

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Research Focus:benchmarking· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein structure· 1

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Alia Clark‐ElSayediD· 1 shared Andrew D. EllingtoniD· 1 shared Ethan CreediD· 1 shared

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1 shared paperSynthetic Biology

Alia Clark‐ElSayedORCID

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Synthetic BiologybioRxivPreprintJul 10, 2025

Comparing LigandMPNN and Directed Evolution for Altering the Effector-Binding Site in the RamR Transcription Factor

Alia Clark‐ElSayed, Ethan Creed, Kaila E. Nayvelt, Andrew D. Ellington

The paper compares LigandMPNN and directed evolution for redesigning the effector-binding site of the RamR transcription factor, finding limited overlap between the two methods' results.

DOI 10.1101/2025.07.10.663684

E. coliprotein structure

𝕏 PostBluesky