Grant M Chou

Connectome simulations identify a central pattern generator circuit for fly walking

The paper identifies a minimal central pattern generator circuit for fly walking using connectome simulations and experimental validation.

A central somatotopic map of the fly leg supports spatially targeted grooming

The paper identifies a somatotopic map in the fly leg that guides targeted grooming through a four-layer neural circuit.

Ascending nociceptive pathways drive rapid escape and sustained avoidance in adult Drosophila

This study identifies abdominal multidendritic neurons as the sole somatosensory class driving rapid escape and sustained avoidance in adult Drosophila through thermal nociception.

Presynaptic inhibition selectively suppresses leg proprioception in behaving Drosophila

The paper identifies a neural circuit in Drosophila that suppresses movement-encoding proprioceptive signals during self-generated leg movements.

Proprioceptive limit detectors mediate sensorimotor control of the Drosophila leg

This study identifies a proprioceptive sensor in Drosophila legs that detects movement limits and mediates sensorimotor reflexes through specific neural connections.

Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking

This study uses a 3D kinematic model of fly walking to show that sensorimotor delays limit robust locomotion, with performance degrading when delays exceed physiological ranges.

Miniature linear and split-belt treadmills reveal mechanisms of adaptive motor control in walking Drosophila

This study uses miniature treadmills to analyze adaptive motor control in Drosophila, showing that kinematics differ between treadmill and free walking, and that mechanosensory neurons affect stepping patterns.

Modeling effects of variable preBötzinger Complex network topology and cellular properties on opioid-induced respiratory depression and recovery

This study uses a computational model of the preBotC network to show that variability in network topology and neuronal properties influences opioid-induced respiratory depression and recovery.