Ryan S. Phillips

Modeling effects of variable preBötzinger Complex network topology and cellular properties on opioid-induced respiratory depression and recovery

This study uses a computational model of the preBotC network to show that variability in network topology and neuronal properties influences opioid-induced respiratory depression and recovery.

Interdependence of cellular and network properties in respiratory rhythmogenesis

The paper uses computational modeling to show that intrinsic bursting and pre-inspiratory spiking can be dissociated from the persistent sodium current in respiratory rhythm generation, supporting a unifying hypothesis involving both cellular and network properties.

Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator

The paper tests and confirms three predictions of a biophysical model of the mammalian respiratory oscillator using optogenetic and pharmacological manipulations in neonatal mouse slices.

Putting the theory into 'burstlet theory': A biophysical model of bursts and burstlets in the respiratory preBötzinger complex

The paper develops a biophysical model explaining respiratory rhythm generation in the preBotC by integrating calcium dynamics and burstlet theory.

A computational model explains and predicts substantia nigra pars reticulata responses to pallidal and striatal inputs

This study combines experimental and computational approaches to explain and predict SNr responses to striatal and GPe inputs, revealing chloride dynamics and GPe's role in modulating SNr activity.

Effects of persistent sodium current blockade in respiratory circuits depend on the pharmacological mechanism of action and network dynamics

This study uses computational simulations to show that different pharmacological mechanisms of sodium current blockade can lead to distinct effects on respiratory circuits, challenging the assumption that all blockers act equivalently.

Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

The paper re-examines the roles of INaP and ICAN in respiratory rhythm generation using a new computational model, finding that ICAN affects amplitude while INaP drives rhythm.