Nathan H. Lazar

This paper builds and benchmarks perturbative maps of transcriptional and morphological data, demonstrating their utility for discovering new biology and highlighting the importance of standardized frameworks.

The paper identifies a proximity bias in CRISPR-Cas9 knockouts, showing phenotypic similarity between unrelated genes on the same chromosome arm, and proposes a correction method.

This study examines how chromosomal rearrangements in the gibbon genome affect TAD boundaries and epigenetic features, finding overlap between rearrangement breakpoints and TAD boundaries.

The paper uses single-cell DNA sequencing in non-human primates to show that chromosomal errors in embryos are encapsulated into micronuclei, fragmented, or excluded to prevent aneuploidy.