Folate metabolism in tumor-associated macrophages drives immunosuppressive function to promote tumor growth
Matthew P. Zimmerman, Vasyl Zhabotynsky, Haiyang Wang, Emily K. Cox, Wan Lin Chong, Alexander Gevelinger Bastian, Andrew S. Kennedy, Brian P Fay, Amy G. Reynolds, Anna Ebacher, Jeremy A. Meier, Katherine J. Vietor, Khalilah E. Taylor, Pristine C. Onuoha, Siddharth Maruvada, , Brian C. Miller
This study identifies folate receptor beta (FRβ) as a metabolic checkpoint on tumor-associated macrophages (TAMs) that promotes immunosuppression and tumor growth.
bioRxiv · Oct 2, 2026 · PreprintImmunology