PHOSPHATIDYLSERINE EXPOSURE AND EXTRACELLULAR ANNEXIN A5 WEAKEN THE ACTIN CORTEX IN OSTEOCLAST FUSION
Evgenia Leikina, Andrey Kimovich Tsaturyan, Kamran Melikov, Jarred M. Whitlock, Jared Cunanan, Morgan Roegner, Griffin Katz, Michael M. Kozlov, Leonid Chernomordik
The paper investigates how phosphatidylserine exposure and Annexin A5 binding weaken the actin cortex during osteoclast fusion, revealing a bidirectional signaling pathway involving Ca2+ and lipid redistribution.
bioRxiv · Jul 16, 2025 · PreprintCell Biology