Kamran Melikov

This study identifies a pathway by which SARS-CoV-2 Spike activates PIEZO1-sphingomyelinase signaling to promote cell-cell fusion through ceramide generation and phosphatase-mediated actin cortex detachment.

This study identifies CLSTN3B as a driver of MASLD by promoting LD biogenesis and altering lipid partitioning between LDs and mitochondria, leading to mitochondrial dysfunction and oxidative stress.

The paper investigates how phosphatidylserine exposure and Annexin A5 binding weaken the actin cortex during osteoclast fusion, revealing a bidirectional signaling pathway involving Ca2+ and lipid redistribution.

This study identifies CLSTN3B as a key protein for adipocyte lipid droplet maturation by facilitating ER-LD contacts, enhancing lipid storage and metabolic health.

This study identifies an oxidized form of La protein at the osteoclast surface, driven by ROS signaling, which promotes multinucleation and bone resorption.