Elevated surface La promotes hyperfusion and contributes to impaired resorption in osteopetrosis.
Jarred M. Whitlock, Evgenia Leikina, Hongyin Wang, Wendy Zhang, Griffin Katz, Nina Bacher Reuven, Ari Elson, Benjamin Geiger, Leonid Chernomordik
This study identifies elevated surface La as a cause of hyperfusion and impaired resorption in osteopetrosis and shows that inhibiting La can restore osteoclast function.
bioRxiv · Sep 7, 2025 · PreprintCell Biology