Synthetic BiologybioRxivPreprint
Coopting T cell proximal signaling molecules enables Boolean logic-gated CAR T cell control
Aidan M. Tousley, Maria Caterina Rotiroti, Louai Labanieh…·Robbie G. Majzner
This paper introduces a novel CAR T cell platform using proximal T cell signaling molecules to enable Boolean logic-gated control, improving efficacy and reducing off-tumor toxicity.
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