Coopting T cell proximal signaling molecules enables Boolean logic-gated CAR T cell control
Aidan M. Tousley, Maria Caterina Rotiroti, Louai Labanieh, Lea Wenting Rysavy, Skyler P. Rietberg, Eva L. de la Serna, Guillermo Nicolás Dalton, Dorota Danuta Klysz, Evan W. Weber, Won‐Ju Kim, Peng Xu, Elena Sotillo, Alexander R. Dunn, Crystal Lee Mackall, Robbie G. Majzner
This paper introduces a novel CAR T cell platform using proximal T cell signaling molecules to enable Boolean logic-gated control, improving efficacy and reducing off-tumor toxicity.
bioRxiv · Jun 17, 2022 · PreprintSynthetic Biology