Manuel Ambrosone

This study shows that Shank3 mutations disrupt cortex-wide dynamics, leading to impaired motor planning in mice.

The paper develops an all-optical system to inhibit cortical neurons and monitor responses, showing widespread suppression of sensory responses after optogenetic silencing.

The paper evaluates functional connectivity in Shank3b mice across ages and brain states, finding age-dependent hyperconnectivity that is anesthesia-sensitive.