Francesco Saverio Pavone

Meditation Styles Are Highly Discriminable from EEG at the Subject Level With Limited Generalization Across the Population: A Machine-Learning Study

This study uses EEG and machine learning to classify meditation styles and mind-wandering, showing high accuracy within individuals but poor generalization across subjects.

Ultrasensitive saliva-based detection of early Alzheimer's disease biomarkers via nanoparticle-enhanced evanescent scattering microscopy

This paper develops a saliva-based diagnostic platform using nanoparticle-enhanced TIRS microscopy to detect early Alzheimer's disease biomarkers with high sensitivity and accuracy.

Myelinated fiber labeling and orientation mapping of the human brain with light-sheet fluorescence microscopy

The paper develops a method to label and map myelinated fibers in human brain tissue using light-sheet fluorescence microscopy and automated image analysis, enabling high-resolution structural characterization.

Quantitative cytoarchitectural phenotyping of deparaffinized human brain tissues

This paper develops a 3D imaging pipeline for automated quantitative cellular phenotyping of FFPE human brain tissues, revealing cytoarchitectural features in patients with cortical development malformations.

Anisotropic light propagation in human brain white matter

This study characterizes anisotropic light scattering in human white matter by measuring tensor components and correlating them with axon fiber orientation.

All-Optical Mapping Reveals Distributed Suppression of Cortical Sensory Responses After Optogenetic Silencing

The paper develops an all-optical system to inhibit cortical neurons and monitor responses, showing widespread suppression of sensory responses after optogenetic silencing.

Age-Dependent Cortical Overconnectivity in Shank3 Mice is Reversed by Anesthesia

The paper evaluates functional connectivity in Shank3b mice across ages and brain states, finding age-dependent hyperconnectivity that is anesthesia-sensitive.

A compact prism-based microscope for high sensitive measurements in fluid biopsy

This paper introduces a compact prism-based microscope for sensitive detection of biomarkers in fluid samples, achieving a 1 fg/mL limit of detection for bacterial lipopolysaccharides.

Two-photon all-optical electrophysiology for the dissection of larval zebrafish brain functional connectivity

The paper develops a two-photon optical system for high-speed volumetric recording and optogenetic stimulation in larval zebrafish to reconstruct functional connectivity of the left habenula.

Frequency-Dependent Inter-Brain Synchrony is Modulated by Social Interaction in Freely Moving Mice

This paper introduces a new platform for hyperscanning in freely moving mice to study inter-brain synchrony during social interaction, finding frequency-dependent synchronization across the cortex.

Cortical mapping of the sensory response reveals strong brain-state dependence of the late component

This study shows that anesthesia levels affect the spatiotemporal features and functional connectivity of sensory-evoked responses in the mouse cortex, with the late component persisting under anesthesia.

Segmentation of supragranular and infragranular layers in ultra-high resolution 7T ex vivo MRI of the human cerebral cortex

This paper introduces a semi-supervised segmentation model for identifying supragranular and infragranular layers in human cerebral cortex MRI scans with high precision.

BRAin-wide Neuron quantification Tool reveals strong sexual dimorphism in the evolution of fear memory

The paper develops BRANT, a tool for whole-brain neuronal activation mapping in mice, revealing strong sexual dimorphism in fear memory circuits.

Large-scale all-optical dissection of motor cortex connectivity reveals a segregated functional organization of mouse forelimb representations

The paper uses all-optical methods in awake mice to reveal a segregated functional organization of forelimb representations in the motor cortex, identifying a new lateral grasping area.

3D molecular phenotyping of cleared human brain tissues with light-sheet fluorescence microscopy

This paper develops a method to 3D molecularly characterize cleared human brain tissues using light-sheet fluorescence microscopy.

A distributed neocortical action map associated with reach-to-grasp

The paper uses calcium imaging to study neocortical dynamics during reach-to-grasp tasks in mice, revealing distributed and localized neural activity patterns.

A multimodal imaging and analysis pipeline for creating a cellular census of the human cerebral cortex

The paper develops an imaging pipeline to create a cell census of the human cerebral cortex using MRI, immunohistochemistry, and light-sheet fluorescence microscopy.

Exploring the human cerebral cortex using confocal microscopy

The paper presents a method combining immunostaining, SWITCH/TDE clearing, and confocal microscopy to map neurons in human cerebral cortex slices, addressing challenges in labeling and clearing.

Cortical propagation as a biomarker for recovery after stroke

This study identifies spatiotemporal propagation indicators from cortical activity in mice to track stroke-induced motor deficits and recovery across different rehabilitation paradigms.

A combined pipeline for quantitative analysis of human brain cytoarchitecture

This paper introduces a pipeline for 3D analysis of human brain cytoarchitecture at micrometer resolution, enabling quantitative evaluation of neuronal density and volume across different brain regions and subjects.

MAGIC: A label-free fluorescence method for 3D high-resolution reconstruction of myelinated fibers in large volumes

The paper introduces MAGIC, a label-free fluorescence method for 3D high-resolution reconstruction of myelinated fibers in large volumes, demonstrating its application on multiple species brain samples.

Experimental and computational study on motor control and recovery after stroke: towards a constructive loop betweenexperimental and virtual embodiedneuroscience

This study integrates experimental and computational models of motor control and recovery after stroke to improve experimental design through continuous data integration and simulation.

Restoration of motor-evoked cortical activity is a distinguishing feature of the most effective rehabilitation therapy after stroke

This study identifies that combined optogenetic stimulation and motor training restores pre-stroke motor-evoked cortical activity, distinguishing it as the most effective post-stroke rehabilitation therapy.

Rehabilitation promotes the recovery of structural and functional features of healthy neuronal networks after stroke

Wide-field imaging of cortical neuronal activity with red-shifted functional indicators during motor task execution

The paper evaluates red-shifted GECIs for in vivo imaging of cortical neuronal activity during motor tasks in mice, finding jRCaMP1a suitable for longitudinal monitoring.

Whole-brain vasculature reconstruction at the single capillary level

This paper introduces a method to reconstruct whole-brain vasculature at the single capillary level using CLARITY, vascular staining, and light-sheet fluorescence microscopy.

Increasing sensitivity and accuracy of brain-wide quantitative studies in light-sheet microscopy

This study demonstrates that Bessel beams improve the sensitivity and accuracy of functional imaging in light-sheet microscopy by reducing artifacts and enhancing detection of calcium transients and activity correlations.

Rehabilitation promotes the recovery of functional and structural features of healthy neuronal networks after stoke

This study shows rehabilitation promotes recovery of both structural and functional features of healthy neuronal networks after stroke in mice.