ImmunologybioRxiv
T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome
Yan Zhao, Hanshuo Zhu, Jinqian Li…·Li Sun
This study identifies EseB, a T3SS translocon protein, as a direct activator of the NLRC4/NAIP inflammasome, inducing pyroptosis in host cells through a conserved mechanism across T3SS-positive bacteria.