Author

Shawn MacGregor

University of Wisconsin–MadisonORCID 0009-0001-4018-5332Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Anita BhattacharyyaiD· 2 shared Nicole R. WestiD· 2 shared André M. M. SousaiD· 1 shared Daifeng WangiD· 1 shared Jose L. Martinez· 1 shared Julien DairouiD· 1 shared Kalpana Hanthanan ArachchilageiD· 1 shared Laurent MeijeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersDevelopmental Biology

Anita BhattacharyyaORCID

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2 papers

Recent·Most cited

Developmental BiologybioRxivPreprintFeb 5, 2026

Leucettinib-21 decreases dosage effects of DYRK1A in human trisomy 21 iPSC-derived neural cells

Nicole R. West, Mattias F. Lindberg, Julien Dairou…·Anita Bhattacharyya

This study shows that Leucettinib-21 reduces DYRK1A activity in human trisomy 21 neural cells, supporting its potential as a therapeutic for Down syndrome.

DOI 10.64898/2026.02.05.704014

humanexperimental assay

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NeuroscienceAlzheimer s & DementiaPeer-reviewedJul 1, 2025

Single-nucleus analysis reveals oxidative stress in Down syndrome basal forebrain neurons at birth

Nicole R. West, Kalpana Hanthanan Arachchilage, Sara Knaack…·Anita Bhattacharyya

The paper uses single-nucleus sequencing to identify oxidative stress and metabolic changes in Down syndrome basal forebrain neurons at birth.

8 citationstop 2%

humanscRNA-seq

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