Author

Nicole R. West

University of Wisconsin–MadisonORCID 0000-0003-0446-4294Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Anita BhattacharyyaiD· 2 shared Shawn MacGregoriD· 2 shared André M. M. SousaiD· 1 shared Ansuman ChattopadhyayiD· 1 shared Daifeng WangiD· 1 shared Ernest Johnson Freeman· 1 shared Jennifer Ann McDonoughiD· 1 shared Joram Rana· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersDevelopmental Biology

Anita BhattacharyyaORCID

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Author profile →

3 papers

Recent·Most cited

Leucettinib-21 decreases dosage effects of DYRK1A in human trisomy 21 iPSC-derived neural cells

Nicole R. West, Mattias F. Lindberg, Julien Dairou, Shawn MacGregor, Sahith Puthireddy, Laurent Meijer, Anita Bhattacharyya

This study shows that Leucettinib-21 reduces DYRK1A activity in human trisomy 21 neural cells, supporting its potential as a therapeutic for Down syndrome.

bioRxiv · Feb 5, 2026 · PreprintDevelopmental Biology

Single-nucleus analysis reveals oxidative stress in Down syndrome basal forebrain neurons at birth

Nicole R. West, Kalpana Hanthanan Arachchilage, Sara Knaack, Shawn MacGregor, Masoumeh Hosseini, Ryan D. Risgaard, Pubudu Kumarage, Jose L. Martinez, Su‐Chun Zhang, Daifeng Wang, André M. M. Sousa, Anita Bhattacharyya

The paper uses single-nucleus sequencing to identify oxidative stress and metabolic changes in Down syndrome basal forebrain neurons at birth.

Alzheimer s & Dementia · Jul 1, 2025Peer-reviewedNeuroscience

NAT8L mRNA oxidation is linked to neurodegeneration in multiple sclerosis

Prakash Kharel, Naveen Kumar Singhal, Nicole R. West, Joram Rana, Lindsey A. Smith, Ernest Johnson Freeman, Ansuman Chattopadhyay, Jennifer Ann McDonough, Soumitra Basu

The paper links NAT8L mRNA oxidation to reduced NAA levels and neurodegeneration in multiple sclerosis.

bioRxiv · Apr 19, 2020 · PreprintMolecular Biology