Author

Lioba Lehmann

University Medical Center of the Johannes Gutenberg University Mainz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioinformatics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 4 Assay:long-read sequencing· 4 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:deep learning· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Mark HelmiD· 4 shared Susanne GerberiD· 4 shared Tamer ButtoiD· 4 shared Anna WierczeikoiD· 3 shared Johannes MiedemaiD· 3 shared Stefan MündnichiD· 3 shared Stefan Pastore· 3 shared Johannes H. FriedrichiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBioinformatics

Mark HelmORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

DModE: An end-to-end framework for Differential Modification and Expression Analysis of Nanopore direct RNA sequencing data

Johannes Miedema, Stefan Pastore, Luca Drescher, Alexander Haehnel, Anna Wierczeiko, Nicolò Alagna, Lioba Lehmann, Mark Helm, Tamer Butto, Susanne Gerber

DModE provides an end-to-end framework for analyzing Nanopore DRS data, enabling integrated differential expression and modification analysis with automated reporting.

bioRxiv · Jun 11, 2026 · PreprintBioinformatics

Mapping human pre-rRNA processing and modification at single nucleotide resolution using long read Nanopore sequencing

Stefan Pastore, Ludivine Wacheul, Lioba Lehmann, Stefan Mündnich, Beat Lutz, Mark Helm, Susanne Gerber, Denis L. J. Lafontaine, Tamer Butto

This study introduces NanoRibolyzer, a long-read nanopore sequencing method to map pre-rRNA processing and modification at single-nucleotide resolution, revealing cleavage sites and modification patterns.

Nature Communications · Mar 31, 2026Peer-reviewedCell Biology

Direct RNA sequencing (RNA004) allows for improved transcriptome assessment and near real-time tracking of methylation for medical applications

Charlotte Hewel, Anna Wierczeiko, Johannes Miedema, Johannes H. Friedrich, Felix Hofmann, Stephan Weißbach, Vincent Dietrich, Laura Holthöfer, Verena Haug, Stefan Mündnich, Lukas Schartel, Lioba Lehmann, Kristi L Jensen, Stefan Diederich, Stanislav Sys, , Susanne Gerber

This study evaluates improvements in direct RNA sequencing (DRS) using RNA004 chemistry and modified-base-calling models, showing enhanced throughput, accuracy, and detection of RNA modifications in clinical applications.

Nucleic Acids Research · Nov 5, 2025Peer-reviewedBioinformatics

ModiDeC: a multi-RNA modification classifier for direct nanopore sequencing

Nicolò Alagna, Stefan Mündnich, Johannes Miedema, Stefan Pastore, Lioba Lehmann, Anna Wierczeiko, Johannes Friedrich, Lukas Walz, Marko Jörg, Tamer Butto, Kristina Friedland, Mark Helm, Susanne Gerber

ModiDeC is a deep-learning classifier that identifies multiple RNA modifications from direct nanopore sequencing, validated on synthetic data and biological samples.

Nucleic Acids Research · Jul 19, 2025Peer-reviewedBioinformatics