BiochemistryNature Chemical BiologyPeer-reviewed
Structural and biochemical basis for cannabinoid cyclase activity in marine bacterial flavoenzymes
Anna C. Love, Harshverdhan Sirohi, Felix M. Hubert…·Bradley S. Moore
This study elucidates the structural and biochemical mechanisms of cannabinoid cyclase activity in marine bacterial enzymes Clz9 and Tcz9, revealing distinct mechanisms from Cannabis cyclases and enabling stereoselective CBCA production.
DOI 10.1038/s41589-026-02257-3