Bradley S. Moore

Convergent routes to haloterpenoid biosynthesis in red algae: identification of non-canonical UbiA-type terpene synthase gene clusters in the genus Laurencia

The paper identifies non-canonical UbiA-type terpene synthase gene clusters in red algae, showing they produce bisabolene and address a biosynthetic puzzle.

Genomic detection of domoic acid biosynthesis uncovers expanded toxigenic diversity across Pseudo-nitzschia diatoms

The paper identifies genomic features of domoic acid biosynthesis in Pseudo-nitzschia diatoms, revealing expanded toxigenic diversity and environmental expression patterns.

A phytocannabinoid-sensitive phosphorylation switch converts endocannabinoids into alternative lipid GPCR activators

The paper shows that phosphorylation of anandamide by DGKQ converts it into AEAp, which acts as a ligand for LPARs and MRGPRX4, linking eCB metabolism to Cannabis pharmacology.

Computational pipeline reveals nature's untapped reservoir of halogenating enzymes

The paper develops a computational pipeline and database to annotate halogenating enzymes in genomic and metagenomic data, revealing underexplored clusters and improving predictions of microbial halogenated natural products.

Structural and biochemical basis for cannabinoid cyclase activity in marine bacterial flavoenzymes

This study elucidates the structural and biochemical mechanisms of cannabinoid cyclase activity in marine bacterial enzymes Clz9 and Tcz9, revealing distinct mechanisms from Cannabis cyclases and enabling stereoselective CBCA production.

Growth-coupled microbial biosynthesis of the animal pigment xanthommatin

This paper introduces a growth-coupled biosynthesis strategy (GrowBio) for producing xanthommatin, demonstrating its effectiveness in microbial production through engineered Pseudomonas putida.

Domoic acid biosynthesis and genome expansion in Nitzschia navis-varingica

This study identifies an expanded domoic acid biosynthesis gene cluster in Nitzschia navis-varingica through genome sequencing and biochemical validation, revealing its unique organization and evolutionary significance.

Discovery and Biosynthesis of Sulfenicin and Its New-to-Nature Acylsulfenic Acid Functional Group

The paper discovers sulfenicin, a novel natural product with a unique acylsulfenic acid functional group, and identifies the enzymes involved in its biosynthesis.

Chromosome-level genome assembly and annotation of Corallium rubrum: a Mediterranean coral threatened by overharvesting and climate change.

This paper presents the first chromosome-level genome assembly and annotation for the red coral Corallium rubrum, providing genomic resources for conservation and population genomics studies.

Giant polyketide synthase enzymes biosynthesize a giant marine polyether biotoxin.

The paper identifies giant polyketide synthase genes in Prymnesium parvum that biosynthesize large polyether toxins, resolving a long-standing biosynthetic mystery.

A modular plasmid toolkit applied in marine Proteobacteria reveals functional insights during bacteria-stimulated metamorphosis

The paper develops a modular plasmid toolkit for genetic manipulation of marine bacteria, demonstrating its use in studying host-microbe interactions and metamorphosis stimulation.

Avant-garde assembly-line biosynthesis expands diversity of cyclic lipodepsipeptide products

The paper reports the heterologous reconstitution of hybrid NRPS-PKS assembly lines that generate a combinatorial library of cyclic lipodepsipeptide protease inhibitors through non-standard biosynthetic mechanisms.