BiochemistryNature CommunicationsPeer-reviewed
Positive cooperativity between RAS-binding and cysteine-rich domains regulates RAF membrane binding kinetics via lateral rebinding
Andres Jimenez Salinas, Kesaria Tevdorashvili, Julian Grim…·Young Kwang Lee
The paper shows how RAF's RBD and CRD domains work together to regulate its membrane binding through lateral rebinding, enhancing signaling specificity in RAS nanoclusters.
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