Author

Lauryn Cook

Cincinnati Children's Hospital Medical CenterORCID 0009-0001-5233-3857Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Zhiyuan CheniD· 2 shared Jian YangiD· 1 shared Jinwen KangiD· 1 shared Mengwen HuiD· 1 shared Peiyao LiuiD· 1 shared Satoshi H. NamekawaiD· 1 shared Shoko IchimuraiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersDevelopmental Biology

Zhiyuan ChenORCID

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2 papers

Recent·Most cited

Developmental BiologyNature CommunicationsPeer-reviewedMar 19, 2026

Polycomb Repressive-Deubiquitinase Complex Safeguards Oocyte Epigenome and Female Fertility by Restraining Polycomb Activity

Jinwen Kang, Peiyao Liu, Shoko Ichimura…·Zhiyuan Chen

This study identifies BAP1 as a key regulator of oocyte epigenome maintenance by restricting Polycomb activity, ensuring proper transcription and female fertility.

1 citation

mouseChIP-seq

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Developmental BiologyCell ReportsPeer-reviewedFeb 20, 2024

Systematic Perturbation of Thousands of Retroviral LTRs in Mouse Embryos

Jian Yang, Lauryn Cook, Zhiyuan Chen

This study uses epigenome editing to perturb thousands of retroviral LTRs in mouse embryos, revealing their role in zygotic genome activation and early development.

32 citationstop 4%

mouseexperimental assay

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