Zhiyuan Chen

The paper shows that H2Aub, not H3K27me3, is the main repressor in chromatin polyvalency, and its disruption causes organogenesis defects in mouse embryos.

This study reveals stage-specific PRC2 functions in preimplantation development and PGC fate through epigenetic dynamics and intercellular communication.

This study identifies BAP1 as a key regulator of oocyte epigenome maintenance by restricting Polycomb activity, ensuring proper transcription and female fertility.

This study uses epigenome editing to perturb thousands of retroviral LTRs in mouse embryos, revealing their role in zygotic genome activation and early development.

The paper shows that DPPA2 and DPPA4 are not required for zygotic genome activation or preimplantation development in mouse embryos, contrasting their role in ESCs.