Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer
Jan-Eric Boekenkamp, Kristina Keuper, Stefan Redel, Karen Barthel, Leah Johnson, Amelie Becker, Angela Wieland, Markus Räschle, Zuzana Štorchová
The paper identifies adaptation strategies in aneuploid cancer cells through in vitro evolution and multi-omics analysis, revealing key transcription factors and genomic changes that improve proliferation and survival.
The EMBO Journal · Feb 10, 2025Peer-reviewedGenetics