Author

James H. Holt

Queen Mary University of LondonORCID 0009-0001-5843-9775Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

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Elena G. BochukovaiD· 1 shared Helen M. RoweiD· 1 shared Pierre V. MaillardiD· 1 shared Rachel P. Wilson· 1 shared Rocio Enriquez-GascaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperMolecular Biology

Elena G. BochukovaORCID

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1 paper

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedJun 16, 2026

Epigenetic lockdown of type I interferon sensing and signalling in human pluripotent cells.

James H. Holt, Rocio Enriquez-Gasca, Rachel P. Wilson…·Helen M. Rowe

This study investigates how the HUSH complex suppresses the type I interferon pathway in human pluripotent cells, revealing its role in preventing self-nucleic acid sensing and maintaining immune evasion.

1 citation

humanbulk RNA-seq

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