Rocio Enriquez-Gasca

Epigenetic lockdown of type I interferon sensing and signalling in human pluripotent cells.

This study investigates how the HUSH complex suppresses the type I interferon pathway in human pluripotent cells, revealing its role in preventing self-nucleic acid sensing and maintaining immune evasion.

Co-option of endogenous retroviruses through genetic escape from TRIM28 repression

The paper tracks the epigenetic fate of endogenous retroviruses during neural differentiation, identifying genetic escapees that evade TRIM28 repression and contribute to gene expression differences.

Transposable elements drive reorganisation of 3D chromatin during early embryogenesis

Hi-C in 2-cell-like mouse cells ties MERVL retroelement transcription to transient insulating domain boundaries, with insertions differing between strains, placing retroelements at the origin of embryonic genome architecture.