Author

Anthony Newman

Australian National UniversityORCID 0009-0001-6093-0010Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Anthony Newman1 paper · Stanford University

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:protein folding & dynamics· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Gaétan BurgioiD· 2 shared Lora M. StarrsiD· 2 shared Aakash SahaiD· 1 shared Giulia PalermoiD· 1 shared Pablo Ricardo ArantesiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Gaétan BurgioORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Nuc domain electrostatics drive the trans cleavage activity of CRISPR-Cas12a

Anthony Newman, Lora M. Starrs, Gaétan Burgio

This study shows that electrostatic interactions in the Nuc domain of Cas12a orthologues regulate trans cleavage activity, with specific mutations enhancing or abolishing cleavage efficiency.

Nucleic Acids Research · Dec 18, 2025Peer-reviewedBiochemistry

CRISPR-Cas12a REC2 - NUC interactions drive target-strand cleavage and constrain trans cleavage.

Anthony Newman, Aakash Saha, Lora M. Starrs, Pablo Ricardo Arantes, Giulia Palermo, Gaétan Burgio

This study investigates differences in cis and trans cleavage efficiency among Cas12a orthologues and identifies REC2-NUC interactions as key determinants of their function.

Nucleic Acids Research · Sep 23, 2025Peer-reviewedBiochemistry