Gaétan Burgio

The paper identifies a bacterial immune pathway where tRNA cleavage generates second messengers that trigger cell death via RNA-guided nuclease activity.

This paper generates a novel Slc7a9G105R mouse model to study cystinuria, identifying new biomarkers and therapeutic insights.

SWARM improves detection of RNA modifications by reducing false positives and reveals new splicing-related pseudouridylation patterns.

This study uses Nanopore DRS to analyze MS2 phage transcriptional dynamics in E. coli, revealing complex transcriptional activity and RNA modifications throughout the life cycle.

This study shows that electrostatic interactions in the Nuc domain of Cas12a orthologues regulate trans cleavage activity, with specific mutations enhancing or abolishing cleavage efficiency.

This study investigates differences in cis and trans cleavage efficiency among Cas12a orthologues and identifies REC2-NUC interactions as key determinants of their function.

This study identifies NTT4/SLC6A17 as a presynaptic glutamine transporter essential for glutamate supply and neurotransmission, with behavioral implications.

The paper uses machine learning to improve Cas12a guide RNA efficiency prediction by analyzing nucleotide bias and mismatches relative to the PAM site.

CHEUI predicts m6A and m5C modifications at single-molecule resolution, revealing co-occurrence of these modifications in mRNAs across cell lines and tissues.

This paper performs a meta-analysis of dual RNA-Seq data from human, mouse, and monkey Plasmodium infections to identify conserved host-parasite interactions and prioritize targets for further study.

The paper identifies high-efficiency HDR target sites using machine learning and develops a tool to design optimal nucleotide editing strategies.

The paper identifies and removes recurrent false positive variants in single genomes to improve the accuracy of variant calling.

The paper tests the ability of NgAgo to edit DNA in mouse zygotes and HEK293T cells but finds no evidence of successful genome editing.