Author

Lora M. Starrs

Australian National UniversityORCID 0000-0001-5771-4969Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Gaétan BurgioiD· 3 shared Anthony NewmaniD· 2 shared A.J. SethiiD· 1 shared Aakash SahaiD· 1 shared Agin RavindraniD· 1 shared Aidan R. O’BrieniD· 1 shared Akanksha SrivastavaiD· 1 shared Alexandra SneddoniD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

Gaétan BurgioORCID

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4 papers

Recent·Most cited

BiochemistryNucleic Acids ResearchPeer-reviewedDec 18, 2025

Nuc domain electrostatics drive the trans cleavage activity of CRISPR-Cas12a

Anthony Newman, Lora M. Starrs, Gaétan Burgio

This study shows that electrostatic interactions in the Nuc domain of Cas12a orthologues regulate trans cleavage activity, with specific mutations enhancing or abolishing cleavage efficiency.

7 citations

proteomicsexperimental assay

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BiochemistryNucleic Acids ResearchPeer-reviewedSep 23, 2025

CRISPR-Cas12a REC2 - NUC interactions drive target-strand cleavage and constrain trans cleavage.

Anthony Newman, Aakash Saha, Lora M. Starrs…·Gaétan Burgio

This study investigates differences in cis and trans cleavage efficiency among Cas12a orthologues and identifies REC2-NUC interactions as key determinants of their function.

14 citationstop 4%

E. colihuman

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BioinformaticsbioRxivPreprintMar 14, 2022

Prediction of m6A and m5C at single-molecule resolution reveals a cooccurrence of RNA modifications across the transcriptome

Pablo Acera Mateos, A.J. Sethi, Agin Ravindran…·Eduardo Eyras

CHEUI predicts m6A and m5C modifications at single-molecule resolution, revealing co-occurrence of these modifications in mRNAs across cell lines and tissues.

19 citations

humanmouse

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GeneticsGenome biologyPeer-reviewedAug 25, 2019

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros…·Atsushi Yoshiki

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.

102 citationstop 3%

mousestatistical model

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