NeurosciencebioRxivPreprint
Seeded aggregation of ANXA11 induces prion-like propagation, TDP-43 co-pathology and nucleocytoplasmic transport defects
Haiyang Luo, Honglin Zheng, Yongting Lu…·Yuming Xu
This study shows ANXA11 forms prion-like amyloid fibrils through phase separation, which propagate between cells, induce TDP-43 pathology, and disrupt nucleocytoplasmic transport, linking ANXA11 dysfunction to ALS/FTD.
DOI 10.64898/2026.03.24.713853