Han Liu

Harnessing the PRDM1-PGC1A axis to enhance CAR T cell efficacy

This study identifies the PRDM1-PGC1A axis as a key regulator of CAR T cell function, showing that inhibiting PRDM1 or activating PGC1A improves CAR T cell efficacy in multiple tumor models.

A sequence-structure dual-match logic enables target recognition fidelity by an IS110 transposon

The paper identifies a sequence-structure dual-match mechanism in IS110 transposons that enhances target recognition fidelity beyond RNA-DNA base pairing.

TSProm: Deciphering the Genomic Context of Tissue Specificity

TSProm identifies tissue-specific gene regulatory elements by training specialized DNA models and using explainable AI to analyze promoter sequences in human tissues.

Seeded aggregation of ANXA11 induces prion-like propagation, TDP-43 co-pathology and nucleocytoplasmic transport defects

This study shows ANXA11 forms prion-like amyloid fibrils through phase separation, which propagate between cells, induce TDP-43 pathology, and disrupt nucleocytoplasmic transport, linking ANXA11 dysfunction to ALS/FTD.

HViLM: A Foundation Model for Viral Genomics Enables Multi-Task Prediction of Pathogenicity, Transmissibility, and Host Tropism

HViLM is a foundation model for viral genomics that predicts pathogenicity, transmissibility, and host tropism across multiple viral families with high accuracy.

Virtual Cells Need Context, Not Just Scale

The paper argues that scaling model capacity alone is insufficient for Virtual Cells, emphasizing the need for contextual diversity and causal representation learning over data volume.

A little longer, a lot better: simulation-guided exploration of extended-length single-end barcoded reads for structural variant detection

This study evaluates long single-end barcoded reads for structural variant detection, showing improved accuracy with longer read lengths compared to short-read and pangenome-based methods.