Exploration of endogenous miRNA-200b/c activity and regulation through a functional dual fluorescence reporter
Paradesi Naidu Gollavilli, Beatrice Parma, Aarif Siddiqui, Hai Yang, Vignesh Ramesh, Francesca Napoli, Annemarie Schwab, Ramakrishnan Natesan, Dirk Mielenz, Irfan Ahmed Asangani, Thomas Brabletz, Christian P. Pilarsky, Paolo Ceppi
The paper uses a fluorescent sensor and CRISPR-Cas9 screening to study miR-200b/c activity and regulation during EMT, identifying upstream regulators and a role for metabolic enzymes.
Oncogene · Mar 2, 2021Peer-reviewedMolecular Biology