Author

Ramakrishnan Natesan

University of PennsylvaniaORCID 0000-0002-7888-9255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Irfan Ahmed AsanganiiD· 3 shared Qu DengiD· 2 shared Aarif SiddiquiiD· 1 shared Annemarie SchwabiD· 1 shared Aqsa Yashfeen· 1 shared Arul M. ChinnaiyaniD· 1 shared Beatrice ParmaiD· 1 shared Benjamin Garcia· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Irfan Ahmed AsanganiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NNMT Loss Drives Cancer Progression by enhancing SAM availability for mTORC1 Signaling and Chromatin Methylation

Qu Deng, Erick Mitchell-Velasquez, Sharan Venkatesh, Rahul Mannan, Hyein Cho, Mohammed Alhusayan, Aqsa Yashfeen, Ramakrishnan Natesan, Natarajan V. Bhanu, Radha Paturu, Javed Siddique, Rohit Mehra, Sooryanarayana Varambally, Benjamin Garcia, David M. Feldser, , Irfan Ahmed Asangani

This study identifies NNMT as a tumor suppressor in prostate cancer that regulates SAM availability, mTORC1 signaling, and chromatin methylation, revealing a therapeutic strategy using dietary methionine restriction and mTORC1 inhibition.

bioRxiv · Jul 1, 2026 · PreprintCancer Biology

Exploration of endogenous miRNA-200b/c activity and regulation through a functional dual fluorescence reporter

Paradesi Naidu Gollavilli, Beatrice Parma, Aarif Siddiqui, Hai Yang, Vignesh Ramesh, Francesca Napoli, Annemarie Schwab, Ramakrishnan Natesan, Dirk Mielenz, Irfan Ahmed Asangani, Thomas Brabletz, Christian P. Pilarsky, Paolo Ceppi

The paper uses a fluorescent sensor and CRISPR-Cas9 screening to study miR-200b/c activity and regulation during EMT, identifying upstream regulators and a role for metabolic enzymes.

Oncogene · Mar 2, 2021Peer-reviewedMolecular Biology

Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19

Qu Deng, Reyaz ur Rasool, Ronnie M. Russell, Ramakrishnan Natesan, Irfan Ahmed Asangani

This study shows androgen regulates ACE2 and TMPRSS2, both critical for SARS-CoV-2 entry, and demonstrates that inhibiting TMPRSS2 or androgen signaling reduces viral entry.

iScience · Jan 1, 2020Peer-reviewedMolecular Biology