Dirk Mielenz

The paper shows that IgA plasma cells co-secrete monomeric and dimeric IgA, challenging the idea that distinct subsets produce only one form.

This study shows glycolytic flux supports human Th1 cell identity and effector function through STAT1 O-glycosylation, with inhibition of glycolysis or O-glycosylation reducing IFN-gamma production.

This study shows EFhd2 promotes mitochondrial spare capacity in B cells during immune synapse formation by stabilizing microtubules.

This study maps the MCU-mediated mitochondrial calcium signaling network using proteomics, identifying 89 new interactors and their roles in disease-related pathways.

The paper uses a fluorescent sensor and CRISPR-Cas9 screening to study miR-200b/c activity and regulation during EMT, identifying upstream regulators and a role for metabolic enzymes.