Irfan Ahmed Asangani

This study identifies NNMT as a tumor suppressor in prostate cancer that regulates SAM availability, mTORC1 signaling, and chromatin methylation, revealing a therapeutic strategy using dietary methionine restriction and mTORC1 inhibition.

This study identifies PTPRK as a gene modulated by TMPRSS2::ERG fusion and a regulatory SNP, showing its role in prostate cancer progression and potential as a biomarker.

The paper shows that H3K36M oncohistone inhibits NSD2, leading to SETD2-dependent antiviral immune response and tumor clearance in KRAS-driven lung cancer.

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

The paper uses a fluorescent sensor and CRISPR-Cas9 screening to study miR-200b/c activity and regulation during EMT, identifying upstream regulators and a role for metabolic enzymes.

This study shows androgen regulates ACE2 and TMPRSS2, both critical for SARS-CoV-2 entry, and demonstrates that inhibiting TMPRSS2 or androgen signaling reduces viral entry.