Author

Chenchu Lin

The University of Texas MD Anderson Cancer CenterORCID 0009-0001-8436-595XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:benchmarking· 2 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:genome assembly· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Traver HartiD· 3 shared Juihsuan Chou· 2 shared Lori WilsoniD· 2 shared Nazanin Esmaeili AnvariD· 2 shared Subin KimiD· 2 shared Xingdi MaiD· 2 shared Annabel K. SangreeiD· 1 shared Christopher J. KempiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersSystems Biology

Traver HartORCID

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintSep 22, 2026

Functional modules predict genetic interactions, revealing evolutionary conservation and rewiring

Chenchu Lin, Veronica Gheorghe, Juihsuan Chou…·Traver Hart

The paper identifies human gene modules enriched for genetic interactions using a combinatorial knockout platform and validates their conservation and rewiring across cancer cell lines.

1 citation

humanexperimental assay

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Systems BiologybioRxivPreprintFeb 11, 2026

Analysis of Combinatorial Knockout CRISPR screens with GRAPE: Genetic interaction Regression Analysis of Pairwise Effects

Juihsuan Chou, Chenchu Lin, Subin Kim…·Traver Hart

GRAPE identifies genetic interactions from combinatorial CRISPR screens with higher precision and recall than existing methods, revealing additional high-confidence interactions in published datasets.

1 citation

humanCRISPR screen

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Systems BiologybioRxivPreprintJan 3, 2023

Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platform

Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma…·Traver Hart

The paper introduces the in4mer CRISPR/Cas12a platform for efficient multiplex gene knockout, demonstrating improved sensitivity and reduced clone numbers compared to CRISPR/Cas9.

8 citations

humanCRISPR screen

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