Author

Juihsuan Chou

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 3 Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:CRISPR screen· 4 Approach:experimental assay· 3 Research Focus:benchmarking· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:database / resource· 1

Frequent Co-Authors

Traver HartiD· 5 shared Nazanin Esmaeili AnvariD· 3 shared Chenchu LiniD· 2 shared Junjie CheniD· 2 shared Subin KimiD· 2 shared Veronica GheorgheiD· 2 shared Alberto CicciaiD· 1 shared Alejandro BuendiaiD· 1 shared

Activity by Year

2022-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersSystems Biology

Traver HartORCID

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Author profile →

5 papers

Recent·Most cited

Functional modules predict genetic interactions, revealing evolutionary conservation and rewiring

Chenchu Lin, Veronica Gheorghe, Juihsuan Chou, Sabriyeh Alibai, Subin Kim, Nazanin Esmaeili Anvar, Yixin Xu, Xingdi Ma, Lori Wilson, Russell D. Moser, Christopher J. Kemp, Jun Chen, Scott Kopetz, Traver Hart

The paper identifies human gene modules enriched for genetic interactions using a combinatorial knockout platform and validates their conservation and rewiring across cancer cell lines.

bioRxiv · Sep 22, 2026 · PreprintSystems Biology

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

Samuel B. Hayward, Alina Vaitsiankova, Tomás Lama-Díaz, Juihsuan Chou, Angelo Taglialatela, Jen‐Wei Huang, Yodharaudshani Wijesekarahanthi, Joshua R. Heyza, Giuseppe Leuzzi, Chuanyuan Chen, Nancy Wong, Tenzin W. Lhakhang, Xi Fu, Alejandro Buendia, Veronica Gheorghe, , Alberto Ciccia

This study uses Cas12a-based knockout screens to identify genetic interactions in the DNA damage response, revealing synthetic lethal and buffering interactions with therapeutic implications.

bioRxiv · Jun 8, 2026 · PreprintGenetics

Analysis of Combinatorial Knockout CRISPR screens with GRAPE: Genetic interaction Regression Analysis of Pairwise Effects

Juihsuan Chou, Chenchu Lin, Subin Kim, Junjie Chen, Traver Hart

GRAPE identifies genetic interactions from combinatorial CRISPR screens with higher precision and recall than existing methods, revealing additional high-confidence interactions in published datasets.

bioRxiv · Feb 11, 2026 · PreprintSystems Biology

Optimal methods for analyzing targeted pairwise knockout screens

Juihsuan Chou, Nazanin Esmaeili Anvar, Reem A. Elghaish, Junjie Chen, Traver Hart

The paper compares methods for identifying synthetic lethal interactions from CRISPR screens and finds ZdLFC provides more consistent results across cell lines.

bioRxiv · Aug 19, 2024 · PreprintSystems Biology

PICKLES v3: the updated database of pooled in vitro CRISPR knockout library essentiality screens

Lance C. Novak, Juihsuan Chou, Medina Colic, Christopher Aaron Bristow, Traver Hart

PICKLES v3 provides an updated database of CRISPR knockout screens in human cell lines, enabling exploration of gene fitness across multiple libraries and cell lines.

Nucleic Acids Research · Nov 3, 2022Peer-reviewedBioinformatics