Veronica Gheorghe

Functional modules predict genetic interactions, revealing evolutionary conservation and rewiring

The paper identifies human gene modules enriched for genetic interactions using a combinatorial knockout platform and validates their conservation and rewiring across cancer cell lines.

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

This study uses Cas12a-based knockout screens to identify genetic interactions in the DNA damage response, revealing synthetic lethal and buffering interactions with therapeutic implications.

Optimal construction of a functional interaction network from pooled library CRISPR fitness screens

This study identifies optimal methods for constructing functional interaction networks from CRISPR knockout screens by evaluating scoring schemes and normalization techniques.

Dynamic rewiring of biological activity across genotype and lineage revealed by context-dependent functional interactions

The paper identifies context-dependent functional interactions from CRISPR screens, revealing how genotype and lineage influence gene coessentiality and pathway rewiring.