A. De Maesschalck

The paper constructs a multi-omics biomolecular network in AML using proteins, metabolites, and histone PTMs to reveal functional entanglement between biomolecules.

The paper uses mass spectrometry to profile histone post-translational modifications in T-ALL cell lines and identifies drug response signatures, but finds discrepancies between in vitro and in vivo models.

iDeepLC improves retention time prediction for peptides with unseen modifications by incorporating chemical structural information, outperforming previous models.