Tim Lammens

The paper shows that different RNase R enzymes from the same supplier can produce inconsistent results in circRNA validation, emphasizing the need for consistent verification with linear controls.

The paper constructs a multi-omics biomolecular network in AML using proteins, metabolites, and histone PTMs to reveal functional entanglement between biomolecules.

The paper uses mass spectrometry to profile histone post-translational modifications in T-ALL cell lines and identifies drug response signatures, but finds discrepancies between in vitro and in vivo models.

This study identifies synergistic effects of second-generation RRM2 and CHK1 inhibitors in neuroblastoma and sarcomas, showing enhanced replication stress and apoptosis.

The paper uses post-mortem tissues to study mutational clonality in healthy tissues, finding smoking-induced clonal changes in oral epithelia and confirming NOTCH1/2-, TP53-, and FAT1-driven clones.

This study demonstrates that reduced representation bisulfite sequencing of cell-free DNA can accurately classify pediatric solid tumors with high sensitivity.