Laura Corveleyn

This study shows that NAD metabolism supports CTCF-cohesin chromatin regulation in EBV-transformed B-cells and identifies NAMPT inhibition as a potential therapeutic strategy.

The paper constructs a multi-omics biomolecular network in AML using proteins, metabolites, and histone PTMs to reveal functional entanglement between biomolecules.

The paper uses mass spectrometry to profile histone post-translational modifications in T-ALL cell lines and identifies drug response signatures, but finds discrepancies between in vitro and in vivo models.

This paper develops a mass spectrometry-based method to profile single-cell histone post-translational modifications, demonstrating its ability to detect treatment responses and chromatin heterogeneity.

This study identifies SET-21 as a novel H3K23 histone methyltransferase that synergizes with SET-32 to promote transgenerational epigenetic inheritance via nuclear RNAi in C. elegans.

The paper provides a roadmap for selecting a bottom-up mass spectrometry protocol for histone analysis by comparing four methods and introducing a new enzyme.