Cancer BiologybioRxiv
αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation
Apoorva Uboveja, Baixue Yang, Raquel Buj…·Katherine M. Aird
This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.
DOI 10.1038/s41586-026-10584-7