Author
The Wistar InstituteORCID 0000-0002-8355-6666Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Aidan R. Cole, Raquel Buj, Apoorva Uboveja…·Katherine M. Aird
This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.
Apoorva Uboveja, Baixue Yang, Raquel Buj…·Katherine M. Aird
This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.
Frank P. Vendetti, Pinakin Pandya, Carina R. Sclafani…·Christopher J. Bakkenist
This study shows that UNG deficiency in tumor cells reduces intrinsic inflammatory signaling and alters interferon sensitivity, leading to a modified tumor microenvironment.
Raquel Buj, Aidan R. Cole, Jeff Danielson…·Katherine M. Aird
This study shows that zinc availability in the tumor microenvironment affects anti-PD1 therapy response in CDKN2A-low tumors through macrophage phagocytosis.
Pinakin Pandya, Frank P. Vendetti, Joseph El-Ghoubaira…·Christopher J. Bakkenist
The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.