Author

Xinyan Han

Second Affiliated Hospital of Zhejiang UniversityORCID 0009-0001-9575-1135Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Boyu WangiD· 2 shared Jian LiuiD· 2 shared Junming LiiD· 2 shared Lian WangiD· 2 shared Manyu XiaoiD· 2 shared Mingyang Xiao· 2 shared Qian TangiD· 2 shared Shirong ZhangiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Boyu WangORCID

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3 papers

Recent·Most cited

A Non-Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zi Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Y Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, , Jian Liu

This study identifies SMAD4 as a regulator of 3D genome architecture in lung squamous cell carcinoma, showing its role in inhibiting tumor development by constraining chromatin looping.

Advanced Science · May 26, 2026Peer-reviewedCancer Biology

Polyclonal-Monoclonal Transition in Lung Squamous Cell Carcinoma Evolution

Taoyu Zhu, Yaping Xu, Junming Li, Zijin Wang, Zhenting Zhang, Boyu Wang, Mingyang Xiao, Boxin Liu, Manyu Xiao, Huiran Wang, Xinyi Xu, Ran Ji, Bo Yang, Songsong Li, Zuolin Shen, , Jian Liu

This study identifies a polyclonal-to-monoclonal evolutionary trajectory in lung squamous cell carcinoma using genomic and transcriptomic data, with implications for precision therapeutics.

bioRxiv · Mar 31, 2026 · PreprintGenomics

Building an atlas of transposable elements reveals the extensive roles of young SINE in gene regulation, genetic diversity, and complex traits in pigs

Pengju Zhao, Lihong Gu, Yahui Gao, Zhangyuan Pan, Lei Liu, Xingzheng Li, Huaijun Zhou, Dongyou Yu, Xinyan Han, Qian LiChun, George E. Liu, Lingzhao Fang, Zhengguang Wang

The paper builds a TE atlas in pigs, showing young SINEs' roles in gene regulation, genetic diversity, and complex traits through multi-omics analysis.

bioRxiv · Feb 7, 2022 · PreprintGenomics